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PROSPECT

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ANZ 1002: PROSPECT

BCT Study Chair:

Bruce Mann

For women diagnosed with early invasive breast cancer, after breast conserving surgery their standard treatment includes radiotherapy given to the affected breast to reduce the risk of breast cancer returning to that breast (local recurrence). PROSPECT is a clinical trial which will use a new technology, breast magnetic resonance imaging (MRI), in combination with review of pathological features of the breast tumour to prospectively identify women who can safely avoid radiotherapy because their risk of local recurrence is very low.

international

-201

INTERNATIONAL

Total number of trial

participants internationally

australia & new zealand

201

AUSTRALIA & NEW ZEALAND

Total number of trial participants

in Australia and New Zealand

institutions

4

INSTITUTIONS

Total number of participating institutions

in Australia and New Zealand

PROSPECT PROTOCOL

PROSPECT TRANSLATIONAL RESEARCH SAMPLES

A single arm phase II study using magnetic resonance imaging (MRI) to select patients with early breast cancer for omission of post-operative radiotherapy (ACTRN12610000810011)

prospect tr | 1

PROSPECT PUBLICATIONS

2024

Quality of life outcomes associated with optimization of treatment by omitting radiotherapy in early breast cancer.

Stafford L, Sinclair M, Butow P, Hughes J, Park A, Gilham L, Rose A, Mann GB. Clinical Breast Cancer. 2024; 1-10, ttps://doi.org/10.1016/j.clbc.2024.03.002, E-pub

What About This IDEA: The PROSPECT That Occult Malignant Lesions May Explain Local Recurrences in Very Early Breast Cancer?

Mann G.B., Rose A.K., Zdenkowski N. Journal of Clinical Oncology. 2024; JCO.23.02729 DOI:10.1200/JCO.23.02729epub 15 March 2024, Correspondence

2023

Postoperative radiotherapy omission in selected patients with early breast cancer following preoperative breast MRI (PROSPECT): primary results of a prospective two-arm study.

Mann GB, Skandarajah AR, Zdenkowski N, Hughes J, Park A, Petrie D, Saxby K, Grimmond SM, Murugasu A, Spillane AJ, Chua BH, Badger H, Braggett H, Gebski V, Mou A, Collins JP, Rose AK. The Lancet. 2023; epub 5 December 2023;DOI:https://doi.org/10.1016/S0140-6736(23)02476-5, E-pub

Is de-escalation of treatment by omission of radiotherapy associated with fear of cancer recurrence and health-related quality of life in women with early breast cancer? An exploratory study.

Mann B, Sinclair M, Butow P, Hughes J, Park A, Gilham L, Rose A, Stafford L. SABCS 2023; PS02-03, Abstract

Is de-escalation of treatment by omission of radiotherapy associated with fear of cancer recurrence in women with early breast cancer? An exploratory study.

Stafford L, Sinclair M, Butow P, Hughes J, Park A, Gilham L, Rose A, Mann G.B. Breast Cancer Research and Treatment. 2023; epub 22 July 2023;[2022 BCT Clinical Fellowship]., doi: 10.1007/s10549-023-07039-2, E-pub

Primary Results of ANZ 1002: Post operative Radiotherapy Omission in selected patients with early breast cancer.

Mann B. RACS Annual Scientific Congress 2023. 2023; Presentation