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RESEARCH DEVELOPMENT AND FUNDING

Breast Cancer Trials supports researchers in developing collaborative, high quality research projects and clinical trials that aim to find new and better treatments and prevention strategies for breast cancer.

BCT welcomes the submission of concepts from all disciplines relevant to breast cancer care, including medical, surgical or radiation oncology, reconstructive surgery, imaging, pathology, and the disciplines involved in supportive care.

The BCT Subgroups in Supportive Care, Systemic Therapy, Translational Research and Very Early Breast Cancer facilitate the creation of scientifically valid research proposals.

Concepts can be submitted at any time. There is also an annual call for concepts for presentation at the Concept Development Workshop at the BCT Annual Scientific Meeting.

Applications are encouraged from non-BCT members, however, for all projects that are approved for ongoing development, investigators must become BCT members. Click here for further information about BCT membership.

Additional information about the BCT trial development process is available to members via the Research section of the website: Research Development and Funding.

Research Types

Discretionary Funding: A one-off grant of up to $50,000 per year, over 1-2 years.

Clinical Trial Development Funding: Supports longer-term research projects (minimum three years) of high strategic value that are unfunded. Projects must be coordinated by the BCT Trials Department.

Discretionary Funding

Discretionary Funding grants are primarily to support small scale research studies such as Pilot studies that have the potential to lead to BCT-coordinated trials.

Funding may be also be considered for sub-studies of protocols BCT is currently involved in, small-scale translational research studies, or projects related to research methodology.

How to Apply

Submit the Concept Proposal Form to the BCT Operational Executive.

The BCT Operational Executive reviews the Concept Proposal to ensure that it meets the aims of the BCT research program and identifies the appropriate SAC Subgroup to support development into a Discretionary Funding Application (BCT will provide the template on approval).

An approved Concept Proposal will be developed with a Concept Development Working Group (CDWG), assisted by the relevant SAC Subgroup.

Researchers may already have specialist researchers to form a CDWG, however the Operational Executive will provide guidance if required. The CDWG must consist of at least two specialist area experts, a statistician and a Consumer Advisory Panel representative.

The Investigator and CDWG develops the Concept Proposal into a Discretionary Funding Application.

The Investigator submits the application to the BCT Operational Executive.

For approved applications, the Investigator completes the Discretionary Funding Agreement with BCT and submits regular reports (as required by the Agreement) during the project.

Clinical Trial Development

To be considered for clinical trial development with BCT, projects must:

  • Fulfil the definition of clinical or translational research that relates to prior, current or the development of future BCT-led breast cancer clinical trials
  • Have the potential to make a significant impact on the care of those affected by breast cancer
  • Be feasible as research with significant involvement from BCT, including being coordinated by the BCT Trials Department
  • Potentially be eligible for competitive funding e.g. NHMRC, MRFF or Cancer Councils.

How to Apply

Concept Proposal and Synopsis Development

Submit the Concept Proposal Form to the BCT Operational Executive.

The BCT Operational Executive initially reviews the Concept Proposal to ensure that it meets the aims of the BCT research program and does not compete with a project that may be in the trials pipeline.

An approved Concept Proposal will be developed into a Project Synopsis (template form provided by BCT on approval of the concept) with a Concept Development Working Group (CDWG), assisted by the relevant SAC Subgroup.

Researchers may already have specialist researchers to form a CDWG, however the Operational Executive/Subgroup Chair will provide guidance if required. The CDWG must consist of at least two specialist area experts, a statistician and a Consumer Advisory Panel representative.

The Investigator and the CDWG develops the Concept Proposal into a Project Synopsis.

The investigator submits the Project Synopsis to the BCT Operational Executive.

Peer Review and SAC Review

The SAC Chair will coordinate peer review of the Project Synopsis; at least two independent experts, a statistician and the CAP will review synopses.

The peer reviews and the Project Synopsis will be presented for discussion and assessment by the Scientific Advisory Committee (SAC). The Investigator will present the project to SAC, including responses to review.

The SAC evaluates the scientific merit and feasibility of project proposals and determines the next steps required to develop the proposal into a Clinical Trial Protocol*.

* Funding options are also considered during this process. If BCT support for a grant application is needed, then BCT support must be confirmed (usually after peer- and SAC-review of the Project Synopsis) and sufficient protocol logistics developed to allow budget formulation. Supply of study treatment or other in-kind support must be confirmed.

Protocol Development

Protocol development is contingent on confirmed funding, supply of study treatment, and approval by the BCT Board of Directors.

Approved projects proceed to Protocol Development, which is coordinated by the BCT Trials Department and supported by the CDWG and relevant SAC Subgroup.

Following protocol endorsement (when the protocol is close to finalisation) by the SAC and Consumer Advisory Panel (CAP), the BCT Trials Department coordinates clinical trial registration and expression of interest with BCT sites; develops patient-related and trial-related documents, data collection and drug management systems; and manages HREC submissions.

BCT Investigator-Initiated Trials

The following clinical trials have been developed via the BCT Clinical Trials Development process:

Discretionary Funding Projects

The following projects have been funded by BCT Discretionary Funding:

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FOR ASSISTANCE

If you would like more information about Research Development and Funding, please email the Breast Cancer Trials Operational Executive.

BCT TRIALS & PROJECTS SUMMARY

A reference table summarising BCT’s current open trials and funded Discretionary Funding projects.

The trial categories, populations, and phases can be filtered to allow researchers to refine areas of interest, identifying potential ideas for future BCT trials.

BCT PROJECT DEVELOPMENT FLOWCHART

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