iPrevent is an online tool to help women understand their breast cancer risk and act on it.

What is iPrevent?

Every woman has an individual breast cancer risk dependent on many things they both can and cannot control such as family history, menopausal status, height, weight, and lifestyle factors such as diet and exercise. By knowing more about your risk and understanding how to change some modifiable factors, you can take appropriate actions to prevent or screen for breast cancer.

iPrevent is an online tool that has been built to help women understand their breast cancer risk and act on it. It has been created by Breast Cancer Trials (BCT) researchers, using data collected from international clinical trials. iPrevent has been created with the intention of facilitating prevention and screening discussions between women and their doctors. 

iPrevent should only be used by women without a personal risk of breast cancer, meaning women who have never received a breast cancer diagnosis.

How does iPrevent calculate my future risk of breast cancer?

iPrevent asks women, or their doctor, to enter family and personal history, lifestyle, and reproductive risk factor information. Using that information, it then provides ten year and residual life-time risk estimates. There are options to view this information as a pictogram or graph. It then provides tailored estimates of the absolute risk reductions for each breast cancer prevention strategy, personalised lifestyle change suggestions and tailored advice on breast cancer screening. There is an option to print out a summary for the woman to take to a consultation with her doctor, and/or so the doctor can incorporate it into the woman’s medical record.

What research is behind this risk calculator?

iPrevent is highly evidence based. It uses the well-validated IBIS and BOADICEA algorithms to estimate each woman’s person risk of breast cancer. An international prospective validation study, conducted using data on more than 16,000 women, has confirmed the accuracy of the risk estimates provided. It uses Cancer Australia guidelines to determine which risk management options women are advised about, based on their risk level. An Australian pilot study of women and doctors has also demonstrated that iPrevent has high usability and acceptability, and suggested that it improves knowledge without increasing anxiety.

How can doctors use iPrevent?

Focus groups conducted with doctors suggest that breast surgeons will find iPrevent particularly useful, not only for managing women at high or moderate risk of breast cancer, but also for reassuring those at average risk. Medical oncologists less frequently see women without a history of cancer, but questions about the risk of healthy family members, such as daughters and sisters often arise during medical oncology consultations. Medical oncologists may suggest that female family members consider using iPrevent and discuss the results with their GP. iPrevent also has an “Information for Clinicians” page that provides background information on the tool, references and tips that can help clinicians with the logistics of prescribing risk-reducing medication.

How is Breast Cancer Trials involved with iPrevent?

BCT provided the initial funding to commence the development of iPrevent, through the generosity of supporters, with further funding provided by the National Health and Medical Research Council. iPrevent was developed by a team of expert BCT doctors, researchers and consumers, including medical oncologist and breast cancer prevention expert, Professor Kelly-Anne Phillips who led the development of iPrevent, breast surgeon and BCT Director of Research Professor Bruce Mann, psychologist Professor Phyllis Butow, medical oncologist Associate Professor Ian Collins and Chair of the BCT Consumer Advisory Panel Ms Leslie Gilham.

Where can I find out more about iPrevent?

More information about the iPrevent tool at www.petermac.org/iPrevent or you can refer to the following publications on iPrevent.

Professor Kelly-Anne Phillips (pictured below) led the development of the iPrevent tool.

OlympiA was led in Australia by Breast Cancer Trials Study Chair and Peter MacCallum Cancer Centre Medical Oncologist, Professor Kelly-Anne Phillips.

iPrevent Publications


Genomic charicterisation of hormone receptor-positive breast cancer arising in young women.

Luen SJ, Viale G, Nik-Zainal S, Savas P, Kammler R, Dell’Orto P, Biasi O, Degasperi A, Brown LC, Lang I, MacGrogan G, Tondini C, Bellet M, Villa F, Bernardo A, Ciruelos E, Karlsson P, Neven P, Climent M, Muller B, Joshum W, Bonnefoi H, Martino S, Davidson NE, Geyer CE Jr, Walley BA, Ingle JN, Coleman R, Solbach C, Thurlimann B, Colleoni M, Coates AS, Goldhirsch A, Fleming GF, Francis PA, Speed TP, Regan MM, Loi S. Annals of Oncology. 2023; epub 25 January 2023, doi: 10.1016/j.annonc.2023.01.009;, E-pub


Adjuvant exemestane with ovarian suppression in premenopausal breast cancer: long-term follow-up of the combined TEXT and SOFT trials.

Pagani* O, Walley* BA, Francis GF, Colleoni M, Láng I, Gomez Hl, Tondini C, Burstein HJ, Goetz MP, Ciruelos EM, Stearns V, Bonnefoi HR, Martino S, Geyer CE Jr, Chini C, Puglisi F, Spazzapan S, Ruhstaller T, Winder EP, Ruepp B, Loi S, Coates AS, Gelber RD, Goldhirsch A, Regan** MM, Francis** PA, for the SOFT and TEXT Investigators and the International Breast Cancer Study Group. *Co-lead authors. **Co-last authors. Journal of Clinical Oncology. 2022; Epub 15 December 2022. doi: 10.1200/JCO.22.01064, E-pub

Adjuvant endocrine therapy in premenopausal breast cancer: 12-year results from SOFT.

Francis* PA, Fleming* GF, Láng I, Ciruelos EM, Bonnefoi HR, Bellet M, Bernardo A, Climent MA, Martino S, Bermejo B, Burstein HJ, Davidson NE, Geyer CE Jr, Walley BA, Ingle, JN, Coleman RE, Müller B, Le Du F, Loibl S, Winer EP, Ruepp B, Loi S, Colleoni M, Coates AS, Gelber RD, Goldhirsch A, Regan MM, for the SOFT Investigators and the International Breast Cancer Study Group. *Co-lead authors. Journal of Clinical Oncology. 2022; Epub 9 December 2022. doi: 10.1200/JCO.22.01065., E-pub

Back to the Beginning: The role of ovarian suppression in management of hormone sensitive breast cancer in premenopausal women.

Connolly RM, Miller RD. Journal of Clinical Oncology. 2022; epub 15 December 2022 doi: 10.1200/JCO.22.02319., Editorial

Development and Validation of a Composite Biomarker Predictive of Palbociclib + Endocrine Treatment Benefit in Early Breast Cancer: PENELOPE-B and PALLAS Trials.

Loibl S, Denkert C, Liu Y, Knudsen ES, DeMichele A, Zhang Z, Teply-Szymanski J, Filipits M, Fasching PA, Gnant M, Deng S, Balic M, Rojo M, Watson M, Deshpande C, Turner N, Metzger O, Theall KP, Witkiewicz A, Valota O, Symmans WF, Mayer EL. San Antonio Breast Cancer Symposium. 2022; Abstract #PD17-05, Abstract

Immunohistochemical markers and determinants of clinical response in the Penelope-B trial.

Knudsen ES, Rachakonda S, Marme F, Marin M, Untch M, Bonnefoi HR, Schmitt WD, Sung-Bai K, Bear HD, Witkiewicz A, Seock-Ah I, DeMichele A, Van’t Veer L, McCarthy N, Sinn BV, Gelmon K, Garcia-Saenz JA, Kelly CM, Reimer T, Turner N, Rojo F, Filipits M, Fasching PA, Schem C, Martin L-A, Liu Y, Toi M, Rugo H, Gnant M, Makris A, Furlanetto J, Weber K, Denkert C, Loibl S. San Antonio Breast Cancer Symposium. 2022; Abstract #PD17-06, Abstract