PROFESSOR GEOFFREY LINDEMAN: BRIDGING RESEARCH AND CLINICAL CARE IN BREAST CANCER

About Professor Geoffrey Lindeman

Professor Geoffrey Lindeman is a clinician-scientist and Joint Head of the ACRF Cancer Biology and Stem Cells Division and Breast Cancer Laboratory. He is also a medical oncologist at the Peter MacCallum Cancer Centre and Royal Melbourne Hospital and holds an honorary appointment as Professorial Fellow in the Department of Medicine, Royal Melbourne Hospital, University of Melbourne.

Professor Lindeman’s primary areas of research include:

• Immunotherapy
• Fundamental biology
• Personalised medicine
• Cell signalling
• Cell death
• Epigenetics
• Transcriptional regulation

Biography

After medical oncology training in Sydney (RPA and Westmead Hospitals), Professor Lindeman obtained his PhD at the Walter and Eliza Hall Institute of Medical Research (Harris and Cory Laboratories), and then pursued postdoctoral training at the Dana-Farber Cancer Institute/Harvard Medical School Livingston Laboratory).

On return to Australia, alongside Professor Jane Visvader, Professor Lindeman established a Breast Cancer Laboratory. His group is studying molecular regulators of normal mammary gland development and cancer, with a particular interest in understanding how mammary stem cells and their progeny contribute to the mammary epithelial cell hierarchy and breast cancer. This work led to the discovery of RANK-positive progenitors as a target for breast cancer prevention in BRCA1 mutation carriers. His laboratory is also using patient derived xenograft (PDX) and tumor organoid models to test promising anti-cancer agents.

Preclinical studies using BH3 mimetics have led to early phase studies of the BCL2 inhibitor venetoclax in breast cancer.

Qualifications and Professional Experience

With a robust academic background and extensive expertise in the medical field, Professor Lindeman holds a Bachelor of Science (Med) and a Bachelor of Medicine, Bachelor of Surgery (Honours) from the University of Sydney, Australia.

Further demonstrating a commitment to excellence, Professor Lindeman is a Fellow of The Royal Australasian College of Physicians, underscoring a high level of professional achievement and recognition. Complementing these qualifications he is also a Doctor of Philosophy (PhD), reflecting a deep engagement in research and a dedication to advancing medical knowledge.

STORIES FROM OUR RESEARCHERS

Our researchers work tirelessly to develop and conduct clinical trials because they see the benefits this research brings to their patients and all those affected by breast cancer.